Long-Term Effects of Semaglutide: What Research Tells Us

Semaglutide is that magical bullet known for making people shed undesirable extra pounds, easily and quickly. But of course, as we know, this specific treatment, and even other treatments of a similar nature, do not alter our hormones permanently. Therefore, practitioners often prescribe semaglutide as a long-term medication to retain the results for the long haul.

Similar to blood pressure and cholesterol management medications, semaglutide is also considered as a long-term medication. There have been studies that aim to gauge the long-term effects of semaglutide, and we are shedding light on it by considering all available research and data.

Are there any Side Effects of Semaglutide?

Unlike weight loss drugs of the past such as amphetamines and now-banned fen-phen that have been known for being addictive and causing severe complications, semaglutide proves to be remarkably safe.

When it comes to the side effects of semaglutide, some patients might face gastrointestinal issues such as diarrhea, nausea, stomach pain, constipation, and heartburn. Doctors can temper these complaints by adjusting the doses, starting patients on a low dosage, and gradually increasing it to an effective yet tolerable level. Some users may also tackle these side effects by taking anti-nausea medications or fiber supplements.

Long Term Effects of Semaglutide

Many speculations exist about the long-term effects of semaglutide. Let’s examine whether these effects are just speculations or if research supports their validity.

Sustained Weight Loss

Semaglutide is primarily used to treat obese patients. However, many believe the medicine only works while you continue taking it, with a clear potential for rebound weight gain once doctors wean you off the drug. Studies show that staying on semaglutide long-term, when combined with behavioral interventions like a healthy diet and exercise, can lead to sustained weight loss over a period of 104 weeks.

Many people believe that long-term use of semaglutide could be harmful to the pancreas and gallbladder. However, some studies indicate that patients who take subcutaneous semaglutide do not face an increased risk of pancreatitis. It is important to note that semaglutide is not an ideal option for patients with a history of pancreatitis or gallstones.

Hypoglycemia is another condition that is often associated as one of the side effects of long-term semaglutide use. However, there is research that follows up with patients after a period of six months of starting semaglutide and suggests that the risk of developing hypoglycemia is low with oral and subcutaneous semaglutide.

Semaglutide also carries a boxed warning about the risk of thyroid tumors. Although this risk was only observed in rodent studies during the drug development phase and has not been seen in humans, it is still important to check the patient's or any family member’s history of thyroid cancer.

Protective Effects on Kidney and Respiratory Illness

Sure, there is enough clinical research that shows positive outcomes for people suffering from diabetes and obesity, but there is also data that regards semaglutide as a great contributor to improving kidney health and respiratory wellness.

A study conducted by Popoviciu et al suggest that semaglutide renders protective effects for the kidney. Another study that examines the association between semaglutide and risk of different respiratory diseases found that semaglutide reduced the risk of respiratory diseases by 18%.

Make An Informed Decision

Just like our body is a nexus of complex systems and organs, these medications and their mechanisms are complicated too. The good thing is that there is research and data to help us make an informed decision and always seek the help of experts. To make semaglutide effective and ensure its safe long-term use, you should get a comprehensive examination and screening done from an expert clinic. It is also important to monitor the progress regularly and track to adjust the dosing if necessary.

Discover how semaglutide can benefit your overall well-being. Schedule a consultation session with our expert here.